From: M. Taylor Saotome-Westlake Date: Sat, 27 Jun 2020 02:53:01 +0000 (-0700) Subject: two more "Human Diversity" anchors X-Git-Url: http://232903.hjopswx29.asia/source?a=commitdiff_plain;h=2aeb30cfa4e44365c043189ec8b236adc63193d0;p=Ultimately_Untrue_Thought.git two more "Human Diversity" anchors --- diff --git a/content/2020/book-review-human-diversity.md b/content/2020/book-review-human-diversity.md index 74d6b9b..0ef782c 100644 --- a/content/2020/book-review-human-diversity.md +++ b/content/2020/book-review-human-diversity.md @@ -35,7 +35,7 @@ These ancestry groupings _are_ a "construct" in the sense that the groupings are Twentieth-century theorists like Fisher and Haldane and whatshisface-the-guinea-pig-guy had already figured out a lot about how evolution works (stuff like, a mutation that confers a fitness advantage of _s_ has a probability of about 2s of sweeping to fixation), but a lot of hypotheses about recent human evolution weren't easy to test or even formulate until the genome was sequenced! -You might think that there wasn't enough _time_ in the 2–5k generations since we came forth out of Africa for much human evolution to take place: a new mutation needs to confer an unusually large benefit to sweep to fixation that fast. But what if you didn't actually need any new mutations? Natural selection on polygenic traits can also act on "standing variation": variation _already_ present in the population that was mostly neutral in previous environments, but is fitness-relevant to new selection pressures. The rapid response to selective breeding observed in domesticated plants and animals mostly doesn't depend on new mutations. +You might think that there wasn't enough _time_ in the 2–5k generations since we came forth out of Africa for much human evolution to take place: a new mutation needs to confer an unusually large benefit to sweep to fixation that fast. But what if you didn't actually need any new mutations? Natural selection on polygenic traits can also act on "standing variation": variation _already_ present in the population that was mostly neutral in previous environments, but is fitness-relevant to new selection pressures. The rapid response to selective breeding observed in domesticated plants and animals mostly doesn't depend on new mutations. Another mechanism of recent human evolution is _introgression_: early humans interbred with our Neanderthal and Denisovan "cousins", giving our lineage the chance to "steal" all their good alleles! In contrast to new mutations, which usually die out even when they're beneficial (that 2s rule again), alleles "flowing" from another population keep getting reintroduced, giving them more chances to sweep! @@ -45,7 +45,7 @@ What do these differences in SNP frequencies mean in practice?? We ... don't kno Sorry, "the Tibetans did it with ..." is sloppy phrasing on my part; what I actually mean is that the Tibetans who weren't genetically predisposed to breathe faster were more likely to die without leaving children behind. That's how evolution works! -The third part of the book is about genetic influences on class structure! Untangling the true causes of human variation is a really hard technical philosophy problem, but behavioral geneticists have at least gotten started with their simple _ACE_ model. It works like this: first, assume (that is, "pretend") that the genetic variation for a trait is _additive_ (if you have the appropriate SNP, you get more of the trait), rather than exhibiting _epistasis_ (where the effects of different loci interfere with each other) or Mendelian _dominance_ (where the presence of just one copy of an allele (of two) determines the phenotype, and it doesn't matter whether you heterozygously have a different allele as your second version of that gene). Then we pretend that we can partition the variance in phenotypes as the sum of the "additive" genetic variance _A_, plus the environmental variance "common" within a family _C_, plus "everything else" (including measurement "error" and the not-shared-within-families "environment") _E_. Briefly (albeit at the risk of being _cliché_): nature, nurture, and _noise_. +The third part of the book is about genetic influences on class structure! Untangling the true causes of human variation is a really hard technical philosophy problem, but behavioral geneticists have at least gotten started with their simple _ACE_ model. It works like this: first, assume (that is, "pretend") that the genetic variation for a trait is _additive_ (if you have the appropriate SNP, you get more of the trait), rather than exhibiting _epistasis_ (where the effects of different loci interfere with each other) or Mendelian _dominance_ (where the presence of just one copy of an allele (of two) determines the phenotype, and it doesn't matter whether you heterozygously have a different allele as your second version of that gene). Then we pretend that we can partition the variance in phenotypes as the sum of the "additive" genetic variance _A_, plus the environmental variance "common" within a family _C_, plus "everything else" (including measurement "error" and the not-shared-within-families "environment") _E_. Briefly (albeit at the risk of being _cliché_): nature, nurture, and _noise_. Then we can estimate the sizes of the _A_, _C_, and _E_ components by studying fraternal and identical twins. (If you hear people talking about "twin studies", this is what they mean—_not_ case studies of identical twins raised apart, which _are_ really cool but don't happen very often.) Both kinds of twins have the same family environment _C_ at the same time (parents, socioeconomic status, schools, _&c._), but identical twins are twice as genetically related to each other as fraternal twins, so the extent to which the identical twins are more similar is going to pretty much be because of their genes. "Pretty much" in the sense that while there are ways in which the assumptions of the model aren't quite true (assortative mating makes fraternal twins more similar in the ways their parents were _already_ similar before mating, identical twins might get treated more similarly by "the environment" on account of their appearance), Murray assures us that the experts assure us that the _quantitative_ effect of these deviations are probably pretty small!